Anderson's focus on slimming down for the beginning of the season seems to have paid off. His 139 yards from scrimmage with two touchdowns largely powered Denver's 21-20 comeback win against the Panthers, whose front seven are among the NFL's best. Jackson has been the most active tackler for the Colts since his signing in 2014, totaling 288 tackles, 81 more than the No. 2 tackler, Jerrell Freeman, who signed with Chicago in free agency. In their season opener, Indianapolis had difficulty corralling Lions running backs Ameer Abdullah and Theo Riddick, who combined for 108 rushing yards, 120 receiving yards and three touchdowns out of the backfield. As the Broncos' top running back, Anderson will have the opportunity to gash Indianapolis similarly, unless Jackson and Co. have something to say about it.