The Broncos' cornerbacks will split time facing the Ravens' wide receivers, who are led by 15-year veteran Steve Smith Sr.
With first-round pick Breshad Perriman injured, Kamar Aiken and Marlon Brown are expected to step up in the second wide receiver spot.
"They're going to be a big part of what we're doing," Baltimore head coach John Harbaugh said. "Obviously, those guys are going to be playing, we have a lot of confidence in those guys and they're ability to make plays. They're a big part of what we do."
Doing their best to stop the Baltimore wide receivers will be Broncos cornerbacks Aqib Talib and Chris Harris, Jr. Both have played Smith before, but Smith will look to start his final NFL season with a bang so the matchup should be a difficult one.