Four different players recorded interceptions in the same game for Denver for the first time since the 2001 campaign.
The 13 penalties for 132 yards called against the Broncos at New York tied for the fifth most penalties and fifth-most penalty yards in franchise history.
The Broncos defense leads the NFL with six interceptions this season.
Denver has won seven consecutive road games to represent the longest such streak in the league. San Diego’s three-game road winning streak is the only other active road win streak in the NFL.
Manning completed 30-of-43 passes for 307 yards with two touchdowns and zero interceptions for a passer rating of 105.5, which tied his own NFL record as his 15th-straight game with a quarterback rating of at least 90.0.
Denver’s defense has broken up a league-best 26 passes this season. The next closest team? Miami with 18.
The Broncos posted 40 points in back-to-back games for just the second time in team history. That last happened in September of 1976 when Denver beat the Jets 46-3 and then the Browns 44-13.
Denver has the league’s top rush defense through Week 2, allowing just 40.5 yards per game.
The Broncos have scored a league-best 90 points this season, including 66 in the second half. The next closest team in scoring is the Packers, who have totaled 66 points.
Manning’s 131.0 passer rating leads the league. He has completed 57-of-85 passes for 769 yards with nine touchdowns and zero interceptions thus far.
Denver’s win against the Giants was the team’s 400th overall win since the 1970 NFL merger. Denver is just the fifth franchise to reach that milestone.
Manning topped the 60,000-yard mark for his career on Denver’s opening drive against the Giants. He joined Brett Favre and Dan Marino as the only players to accomplish that feat and is the fastest of the three to hit that mark, needing just 7,841 attempts.